Endocannabinoid news

The endocannabinoid system of the skin in health and disease: novel perspectives and therapeutic opportunities


An interesting research paper from the NIH on the newly discovered cutaneous endocannabinoid system. The therapeutic potential of cannabinoids to control cell proliferation should warrant further studies. Too bad our lawmakers most likely never bother to read such studies. It probably flies well over their heads.

Here is the conclusion of the paper: “Collectively, it seems that the main physiological function of the cutaneous ECS is to constitutively control the proper and well-balanced proliferation, differentiation and survival, as well as immune competence and/or tolerance, of skin cells. Pathological alterations in the activity of the fine-tuned cutaneous ECS might promote or lead to the development of certain skin diseases. Therefore, it is envisaged (this is also strongly supported by pilot studies) that the targeted manipulation of the ECS (aiming to normalize the unwanted skin cell growth, sebum production and skin inflammation) might be beneficial in a multitude of human skin diseases. However, to predict the real therapeutic potential and translate the exciting preclinical observations discussed earlier into clinical practice, numerous important questions should carefully be addressed (Box 2). Nevertheless, targeting the cutaneous ECS for therapeutic gain remains an intriguing and provocative possibility warranting future studies.”

Further recommended readings:

“The Endocannabinoid System as an Emerging Target of Pharmacotherapy” http://pharmrev.aspetjournals.org/content/58/3/389.short

“Endocannabinoids Modulate Human Epidermal Keratinocyte Proliferation and Survival via the Sequential Engagement of Cannabinoid Receptor-1 and Transient Receptor Potential Vanilloid-1” http://www.nature.com/jid/journal/v131/n5/full/jid2010421a.html

Author: Jeffrey Dhywood

Jeffrey Dhywood is a European-born investigative writer, lecturer and public speaker, drug policy analyst, author of "World War D – The Case against prohibitionism, roadmap to controlled re-legalization" http://www.world-war-d.com/. Jeffrey Dhywood holds a degree in Mathematical logics (Model Theory). He lived 20 years in the US and is currently living in Latin America. He is also very familiar with Asia, which gives him a good grasp of the global dimension of the War on Drugs, and its global failure. His academic background and his direct experience allows him to bring common sense and sanity to an issue often mired in confusion, misconceptions and preconceptions.

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